| 期刊全称 | 26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla | | 影响因子2023 | Keith E. Herold,Jafar Vossoughi,William E. Bentley | | 视频video | http://file.papertrans.cn/101/100580/100580.mp4 | | 发行地址 | Presents the Proceedings of the 26th Southern Biomedical Engineering Conference, College Park, MD, USA All research papers are double peer reviewed | | 学科分类 | IFMBE Proceedings | | 图书封面 |  | | 影响因子 | The 26th Southern Biomedical Engineering Conference was hosted by the Fischell Department of Bioengineering and the A. James Clark School of Engineering from April 30 – May 2 2010.. The conference program consisted of 168 oral presentations and 21 poster presentations with approximately 250 registered participants of which about half were students. The sessions were designed along topical lines with student papers mixed in randomly with more senior investigators. There was a Student Competition resulting in several Best Paper and Honorable Mention awards. There were 32 technical sessions occurring in 6-7 parallel sessions. This Proceedings is a subset of the papers submitted to the conference. It includes 147 papers organized in topical areas. Many thanks go out to the paper reviewers who significantly improved the clarity of the submitted papers. | | Pindex | Conference proceedings 2010 |
| 1 |
Front Matter |
|
|
Abstract
|
| 2 |
Traumatic Brain Injury in Rats Caused by Blast-Induced Hyper-Acceleration |
G. Fiskum,J. Hazelton,R. Gullapalli,W. L. Fourney |
|
Abstract
Well over 100,000 U.S. warfighters in Iraq and Afghanistan have sustained some form of traumatic brain injury. Most of these injuries have been due to exposure to blasts. Of these victims, approximately 20% have been passengers within vehicles that were targets of roadside improvised explosive devices. The hyper-acceleration experienced by these victims can result in exposure to g-forces much greater than those that cause loss of consciousness, a clinical symptom of mild traumatic brain injury. We have developed an experimental paradigm to study the effects of blast-induced hyper-acceleration on laboratory rats to gain insight into mechanisms responsible for brain injury. Our hypothesis is that g-forces in the range of 20 – 40 g can induce mild brain injury without causing other injuries that are lethal. The preliminary results of brain histology measurements that probe for the degeneration or structural disorganization of neurons support this hypothesis. The significance of these studies is that they could eventually lead to improved designs of military vehicles that better protect against blast-induced neurologic injury. Moreover, the use of accelerometers and other sensors in th
|
| 3 |
Early Metabolic and Structural Changes in the Rat Brain Following Trauma , Using MRI |
S. Xu,J. Zhuo,J. Racz,S. Roys,D. Shi,G. Fiskum,R. Gullapalli |
|
Abstract
Traumatic brain injury (TBI) is characterized by acute physiological changes that may play a significant role in the final outcome for the patient. The understanding of tissue alterations at an early stage following TBI is critical for injury management and prevention of more severe secondary damage. In this study we investigated the early post-traumatic neuro-metabolic changes, and changes in tissue water diffusion using proton magnetic resonance spectroscopy (.H MRS) and diffusion tensor imaging (DTI) following mild to moderate controlled cortical impact injury on six adult male Sprague-Dawley rats on a 7.0 Tesla animal MRI system. Significant reduction in N-acetylaspartate, glutamate and choline was observed as early as 3 hours following injury. Lactate continued to increase in the ipsilateral hippocampus even at 5 hours indicating increased demands for energy closer to the injury site. Such changes were not observed on the contralateral side at 5 hours. Decreased apparent diffusion coefficient and increased fractional anisotropy was observed among regions in close proximity to impacted regions (ipsilateral hippocampus and bi-lateral thalamus) immediately following TBI, with the
|
| 4 |
Principal Components of Brain Deformation in Response to Skull Acceleration: The Roles of Sliding an |
Teresa M. Abney,Y. Aaron Feng,Robert Pless,Ruth J. Okamoto,Guy M. Genin,Philip V. Bayly |
|
Abstract
The relationship between skull acceleration and brain injury is not well understood, in large part because of the challenge of visualizing the brain’s mechanical response in vivo. This difficulty also complicates the validation of computational mechanics predictions..Our dynamic magnetic resonance (MR) imaging suggests an important role for the attachments between brain and skull. Here, we present an MRI-based method for identifying the dominant modes of brain displacement relative to the skull during angular acceleration of the head, and apply it to study brain/skull interactions in live volunteers. The approach was to estimate dynamic intracranial displacement fields from a sequence of tagged MR images of the brain and skull, then identify dominant displacement modes using principal component (PC) analysis. After verifying the method through analysis of a simulated 2-D vibrating plate and MR images of a cylindrical gel phantom, the method was applied to show that the dominant mode of brain/skull interaction is one of sliding arrested by brain/skull meninges in a few specific regions.
|
| 5 |
Investigations into Wave Propagation in Soft Tissue |
M. F. Valdez,B. Balachandran |
|
Abstract
In this article, the authors investigate wave propagation in soft-tissue matter with the aim of understanding the following: i) influence of nonlinear material properties of soft tissue on its mechanical response when subjected to transient loading and ii) mechanical response variation with respect to frequency and amplitude of the loading. To aid these investigations, reduced-order models are constructed taking into account available experimentally determined brain tissue properties and these models are used to study one-dimensional wave propagation in brain tissue fiber bundles. These investigations could help in furthering the understanding of wave phenomena in a skull-brain system subjected to transient loadings.
|
| 6 |
Correlating Tissue Response with Anatomical Location of mTBI Using a Human Head Finite Element Model |
T. P. Harrigan,J. C. Roberts,E. E. Ward,A. C. Merkle |
|
Abstract
Mild traumatic brain injury (mTBI) has recently been shown to include deficits in cognitive function that have been correlated to changes in tissue within regions of the white matter in the brain. These localized regions show decreased anisotropy in water diffusivity, which are thought to be related to local mechanical damage. However, a specific link to mechanical factors and tissue changes in these regions has not been made. This study is an initial attempt at such a correlation. A human head finite element model, verified against experimental data under simulated blast loading conditions, was used to estimate strains within regions in the brain that are correlated to functional deficits. Strain values from the most anterior and posterior extent of the corpus callosum (the rostrum and the splenium), the right and left anterior and posterior limb of the internal capsule (ALIC and PLIC), and the left cingulum bundle were calculated under frontal blast loading at overpressure intensities below those typically known to cause injury. Strain peaks of approximately 1 percent were noted in regions associated with cognitive brain injury, indicating that loading conditions which involve hi
|
| 7 |
Human Surrogate Head Response to Dynamic Overpressure Loading in Protected and Unprotected Condition |
A. C. Merkle,I. D. Wing,J. C. Roberts |
|
Abstract
The ballistic performance of helmets has contributed to increased soldier survivability through the prevention of penetrating injuries. However, the efficacy of helmets in mitigating primary blast–induced traumatic brain injury (bTBI) is unclear. The objective of this effort was to utilize the Human Surrogate Head Model (HSHM) to investigate brain response to shock tube overpressure loading conditions, both with and without personal protective equipment (PPE). The HSHM is a physical surrogate which includes a brain, skull, facial structure and skin, all fabricated using biosimulant materials. The system was mounted to a Hybrid III Anthropomorphic Test Device neck to allow head motion during overpressure exposure. Pressure sensors were embedded along the sagittal plane in the anterior and posterior regions of the biosimulant brain. A series of shock tube tests using driver pressures at four levels (ranging from 420 to 1150 kPa) were conducted to simulate blast loading conditions. Internal pressure response was highly correlated to driver pressure, thus demonstrating the surrogate models sensitivity to load conditions. Characteristic features observed in the archetypical pressure wav
|
| 8 |
Blast-Induced Traumatic Brain Injury: Using a Shock Tube to Recreate a Battlefield Injury in the Lab |
|
|
Abstract
|
| 9 |
Wave Propagation in the Human Brain and Skull Imaged ,by MR Elastography |
E. H. Clayton,G. M. Genin,P. V. Bayly |
|
Abstract
Traumatic brain injuries (TBI) are common, and often lead to permanent physical, cognitive, and/or behavioral impairment. TBI arises in vehicle accidents, assaults, athletic competition, and in battle (due to both impact and blast). Despite the prevalence and severity of TBI, the condition remains poorly understood and difficult to diagnose. Computer simulations of injury mechanics offer enormous potential for the study of TBI; however, computer models require accurate descriptions of tissue constitutive behavior and brain-skull boundary conditions. Lacking such data, numerical predictions of brain deformation remain uncertain. Brain tissue is heterogeneous, anisotropic, nonlinear, and viscoelastic. The viscoelastic properties are particularly important for TBI, which usually involves rapid deformation due to impact..Magnetic resonance elastography (MRE) is a non-invasive imaging modality that provides quantitative spatial maps of biologic tissue stiffness .. MRE is performed by inducing micron-amplitude propagating shear waves into tissue with a surface actuator at steady state while images of the wave motion are acquired using a standard clinical MRI scanner. A custom synchronize
|
| 10 |
Cavitation as a Possible Traumatic Brain Injury (TBI) Damage Mechanism |
Andrew Wardlaw,Jack Goeller |
|
Abstract
Cavitation has been proposed as a damage mechanism for traumatic brain injury. This paper uses simulation of simplified head models to determine the plausibility of cranial cavitation during blast events. Of particular interest is CSF which is treated with a cavitation model developed and validated for water. Ellipsoid as well as 3-D head models are considered that consist of a skull, brain matter and CSF. Simulations, conducted with a coupled fluid-structure hydrocode, suggest that cranial cavitation will occur during blast events, particularly at the contrecoup site.
|
| 11 |
Prognostic Ability of Diffusion Tensor Imaging Parameters among Severely Injured Traumatic Brain Inj |
Joshua F. Betz,Jiachen Zhuo,Anindya Roy,Kathirkamanthan Shanmuganathan,Rao P. Gullapalli |
|
Abstract
Diffuse axonal injury (DAI) represents the most common primary intra-axial form of traumatic brain injury (TBI), comprising approximately half of all such injuries. Patients presenting with DAI follow a highly variable clinical course, with initial status frequently discrepant from long-term neurological outcome. Diffusion Tensor Imaging (DTI) is sensitive to disruptions in neuronal structure that may not be appreciated on CT or conventional MRI and may serve as an important prognostic imaging marker. In this study, we retrospectively evaluated the data from 84 patients to determine if the whole brain DTI parameters (axial diffusivity ., radial diffusivity ., apparent diffusion coefficient ADC, and fractional anisotropy FA) are predictive of their clinical outcome as determined by discharge Glasgow Coma Scale (GCS). The first group consisted of 52 severely injured patients (GCS≤8) that either died (n=10), had poor outcome (n=12) or good outcome (n=27). The second group was comprised of mildly injured patients (GCS≥14 during entire hospitalization) that served as the reference group. Whole brain measurements of the DTI parameters were measured on each patient, and using non-parametr
|
| 12 |
Hair Cell Regeneration in the Mammalian Ear, Is Gene Therapy the Answer? |
Matthew W. Kelley |
|
Abstract
In vertebrates the sensation of hearing is dependent on the presence of mechanosensory hair cells located within the coiled cochlea of the inner ear. The apical surface of each hair cell contains a specialized stereociliary bundle that acts to detect sound-induced pressure waves. In mammals, hair cells are only generated during a finite period in embryogenesis. Therefore, hair cell loss, as a result of either genetic or environmental factors, leads to a permanent loss in hearing acuity. Recent results have identified some of the genes that are instructive for the formation of hair cells. In particular, forced expression of the basic helix-loop-helix transcription factor, Atoh1, was found to be sufficient to induce hair cell formation in different cell types within the embryonic inner ear. These findings suggested that expression of Atoh1 within a damaged mammalian inner ear might be sufficient to induce the formation of new hair cells. In fact, studies in mature animals that can spontaneously regenerate hair cells, such as birds, indicates that re-expression of Atoh1 is a key step in this process. In contrast, existing data indicates that Atoh1 is never re-expressed in a mature mam
|
| 13 |
Magnetoencephalography and Auditory Neural Representations |
|
|
Abstract
|
| 14 |
Voice Pitch Processing with Cochlear Implants |
Monita Chatterjee,Shu-Chen Peng,Lauren Wawroski,Cherish Oberzut |
|
Abstract
Cochlear implants today allow many severe-to-profoundly hearing-impaired individuals to hear and understand speech in everyday settings. However, the transmission of voice pitch information via the device is severely limited. Other than limiting their appreciation of music, the lack of pitch information means that cochlear implant patients have difficulty with speaker/gender recognition, intonation and emotion perception, all of which limit speech communication in everyday life. In electrical stimulation via cochlear implants, the fine spectral detail necessary for conveying the harmonic structure of F0, is not available. Although the spectral cues for pitch are lost, the temporal periodicity cue for pitch may still be available to the listener after speech processing. Our previously published results indicate that adult cochlear implant listeners are sensitive to this periodicity cue and are able to use it in a voice-pitch-based intonation identification task. Ongoing experiments also suggest that different mechanisms may play a role in processing the temporal pitch cue when multiple channels are concurrently stimulated, rather than when a single channel is stimulated. Initial exp
|
| 15 |
Transcranial Magnetic Stimulation as a Tool for Investigating and Treating Tinnitus |
G. F. Wittenberg |
|
Abstract
Transcranial magnetic stimulation (TMS) is a technique that allows non-invasive, painless stimulation of neuronal structures, based on electromagnetic induction of electric fields in excitable tissue. The technique has been applied to investigate normal physiology and disease states. TMS has therapeutic potential, as repetitive stimulation (RTMS) can produce long-term modulation of neuronal circuits. RTMS has been demonstrated to be an effective treatment for depression and is being developed for use in neurorehabilitation..TMS is delivered by discharge of high-voltage capacitors through copper coils applied to the scalp, with induction of a rapidly changing magnetic field that easily penetrates the skull. Besides brain stimulation, other effects of such a discharge are a clicking noise, stimulation of sensory fibers in the scalp, and heating of the coil and nearby conductors. It may be difficult to distinguish which effects are important in tinnitus investigations, particularly if the coil noise and scalp sensory stimulation are not controlled. Localization of stimulation is another problem in TMS work, as coils may be accurately placed over brain areas but then produce significan
|
| 16 |
A Course Guideline for Biomedical Engineering Modeling and Design for Freshmen |
W. C. Wong,E. B. Haase |
|
Abstract
Johns Hopkins University’s Biomedical Engineering (BME) Department Freshmen Modeling and Design course provides a taste of BME by integrating first-order modeling of physiological systems with quantitative experimentation at a level that freshmen students can understand. It is a team-based course from both instructor and student perspectives, combining lectures with practical and project components..The freshmen teams consist of 5-6 students, each mentored by a faculty adviser, and guided by a graduate student teaching assistant and upperclassmen BME lab managers. Projects are completed and graded as a group. To encourage teamwork and participation, a peer evaluation system is employed, in which a student receives a modified grade based on the group’s grade and their personal contributions to the project..For a cohort of about 130 freshmen, typically more than 20 faculty members, 12 graduate student teaching assistants and 14-18 BME upperclassmen lab managers are involved, which is a unique aspect of this course. By putting freshmen students into close contact with many members of faculty and student body, this course aims to serve as a springboard for students to explore the diver
|
| 17 |
Classroom Nuclear Magnetic Resonance System |
C. L. Zimmerman,E. S. Boyden,S. C. Wasserman |
|
Abstract
A low-field classroom NMR system was developed that will enable hands-on learning of NMR and MRI concepts in a Biological Engineering laboratory course. A permanent magnet system was built to produce a static field of B. = 0.133 Tesla. A single coil is used in a resonant probe circuit for both transmitting the excitation pulses and detecting the NMR signal. An FPGA is used to produce the excitation pulses and process the received NMR signals. This research has led to the ability to observe Nuclear Magnetic Resonance. Relaxation time constants of glycerin samples can easily be measured. Future work will allow further MRI exploration by incorporating gradient magnetic field coils.
|
| 18 |
The Basics of Bioengineering Education |
Arthur T. Johnson |
|
Abstract
Bioengineering education often tends towards applied biological science. However, engineering is a profession different from the discipline of biological science. This difference should be maintained in undergraduate bioengineering education. A curriculum based upon fundamentals of engineering, science, math, and liberal studies can give students the flexibility they need to master the challenges of future employment.
|
| 19 |
HealthiManage: An Individualized Prediction Algorithm for Type 2 Diabetes Chronic Disease Control |
Salim Chemlal,Sheri Colberg,Marta Satin-Smith,Eric Gyuricsko,Tom Hubbard,Mark W. Scerbo,Frederic D. |
|
Abstract
This paper describes a prediction algorithm for blood glucose in Type 2 diabetes. An iPhone application was developed that allows patients to record their daily blood glucose levels and provide them with relevant feedback using the prediction algorithm to help control their blood glucose levels. Several methods using theoretical functions were tested to select the most accurate prediction method. The prediction is adjusted with each glucose reading input by the patient taking into consideration the time of the glucose reading and the time after the patient’s last meal, as well as any physical activity. The individualized prediction algorithm was tested and verified with real patient data and also validated using a non-parametric regression method. The accuracy of prediction results varied from different approaches and was adequate for most of the methods tested. The predicted results merged closer to the patients’ actual glucose readings after each additional input reading. The findings of the research were encouraging and the predictive system provided what we believe to be helpful feedback to control, improve, and take proactive measures to regulate blood glucose levels.
|
| 20 |
Dynamic Movement and Property Changes in Live Mesangial Cells by Stimuli |
Gi Ja Lee,Samjin Choi,Jeong Hoon Park,Kyung Sook Kim,Ilsung Cho,Sang Ho Lee,Hun Kuk Park |
|
Abstract
Atomic force microscopy (AFM) has become an important device to visualize various cells and biological materials for non-invasive imaging. The major advantage of AFM compared to the conventional optical and electron microscopes is its convenience. Sample preparation for AFM does not need special coating or vacuum as a procedure. AFM can detect samples even under the aqueous condition. Although the AFM is originally used to obtain surface topography of sample, it can measure precisely the interactions between its probe tip and the sample surface from force-distance measurements..Glomerular mesangial cells (MC) occupied central position in the glomerulus. It is known that MC can control not only glomerular filtration, but also cell response to local injury including cell proliferation and basement membrane remodeling. It was reported the increment of angiotensin II by activation of rennin angiotensin aldosterone system (RASS) caused abnormal function of MC..In this study, we observed structural and mechanical changes to MC after Ang II treatment using AFM. Real time imaging of live cell suggested dynamical movement of cells was stimulated by angiotensin II injection. Simultaneously,
|
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla影响因子(影响力)
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla影响因子(影响力)学科排名
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla网络公开度
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla网络公开度学科排名
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla被引频次
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla被引频次学科排名
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla年度引用
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla年度引用学科排名
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla读者反馈
书目名称26th Southern Biomedical Engineering ConferenceSBEC 2010 April 30 - May 2, 2010 College Park, Maryla读者反馈学科排名
|
|
|
|Archiver|手机版|小黑屋|
派博传思国际
( 京公网安备110108008328)
GMT+8, 2025-7-22 13:53
发表于 2025-3-21 18:01:00
