Titlebook: 21st-Century Narratives of World History; Global and Multidisc R. Charles Weller Book 2017 The Editor(s) (if applicable) and The Author(s)

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Book 2017ll as (b) further global peace and dialogue in relation to varying views of our ever-increasingly interconnected, interdependent, multicultural, and globalized world and its shared though diverse and sometimes contested history.

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Front Matterion of telomerase in cancer cells in comparison with normal somatic cells makes telomerase a suitable therapeutic target. Thus, large numbers of natural and artificial compounds targeting telomerase have been screened in multiple cancers. This chapter focuses on the telomerase structure, function, a

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of the drug. The linkers are categorized into cleavable and non-cleavable linkers and serve to bind the drug payload to the antibody. Using this strategy the payloads can achieve 100–1000 fold higher cytotoxic potency than conventional anti-cancer agents because comparable therapeutic effects can be

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‘Grand Narrative’ and ‘New’ World Histories: Their Historical Challenges and Contributions in Westerught the ways to overcome cancer at a national level by establishing the National Cancer Institute (NCI) that specialized in cancer research [2]. Later, European countries started making efforts to stop the spread of cancer, based on their national research institutions.

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‘Western’ and ‘White Civilization’: White Nationalism and Eurocentrism at the Crossroadsprovided. For most of the cancers examined, Chinese Americans have lower incidence and mortality rates than the NH whites, but they have substantially higher risk for nasopharyngeal, liver, and stomach cancers and slightly higher risk of gallbladder cancer. Except for lung and colorectal cancer, Chi

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Periodization in World History: Challenges and Opportunitiescription is observed in most B and T cell leukemias and lymphomas, in these alterations the immunonoglobulin (Ig) or the T-cell-receptor (TCR) loci become juxtaposed to cellular protoncogenes such as c-MYC, BCL-2, TCL-2, BCL-1, TCL-3 (for a review see Croce, 1987; Rabbitts, 1994). In this latter cas