Picks-Disease 发表于 2025-3-25 04:14:26
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https://doi.org/10.1007/978-3-8348-8620-0ons in human helicase genes are responsible for a variety of genetic disorders and are associated with tumorigenesis. A number of missense mutations in human helicase genes are linked to chromosomal instability diseases characterized by age-related disease or associated with cancer, providing incentEWE 发表于 2025-3-25 18:34:43
https://doi.org/10.1007/978-3-8348-8620-0unmet clinical need for improved herpes antivirals. The successful compounds, acyclovir; penciclovir and their orally bioavailable prodrugs valaciclovir and famciclovir, ultimately block virus replication by inhibiting virus-specific DNA-polymerase. The helicase–primase (HP) complex offers a distinc保存 发表于 2025-3-25 20:23:50
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https://doi.org/10.1007/978-3-658-27654-6integrity of the DNA. Helicases often play a central role in these repair pathways and have shown to be essential for diverse tasks within these mechanisms. In prokaryotic nucleotide excision repair (NER) for example the two helicases UvrB and UvrD assume vastly different functions. While UvrB is inVenules 发表于 2025-3-26 11:22:18
https://doi.org/10.1007/978-3-658-27654-6ands. A more encompassing taxonomy that captures alternative enzymatic roles has defined helicases as a sub-class of molecular motors that move directionally and processively along nucleic acids, the so-called “translocases”. However, even this definition may be limiting in capturing the full scope词汇表 发表于 2025-3-26 13:11:41
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