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Structure and Mechanisms of SF1 DNA Helicases, involved in essential processes in both DNA and RNA metabolism in all organisms. In addition to conserved amino acid sequences, they also share a common structure containing two RecA-like motifs involved in ATP binding and hydrolysis and nucleic acid binding and unwinding. Unwinding is facilitated推迟 发表于 2025-3-22 02:28:28
Structure and Mechanisms of SF2 DNA Helicases,ons that constitute these processes. Many of these machines use single-stranded nucleic acids as templates, and their actions are often regulated by the participation of nucleic acids in multimeric structures and macromolecular assemblies that restrict access to chemical information. Superfamily IIadhesive 发表于 2025-3-22 06:09:18
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RecQ Helicases: Conserved Guardians of Genomic Integrity,RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5. Defects in three of these give rise to Bloom’s syndrome (BLM), Werner’s syndrome (WRN) and Rothmund–Thomson/RAPADILINO/Baller–Gerold (RECQ4) syndromes. These syndromes are characterised by cancer predisposition and/or premat代替 发表于 2025-3-23 03:07:55
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