Titlebook: Use Case Driven Object Modeling with UMLTheory and Practice; Theory and Practice Doug Rosenberg,Matt Stephens Book 2007Latest edition Don R

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r insight into the data generating mechanism by explaining the variability in the data. The choice of residual variance model should be based on the data and theoretical considerations of the data and what is known about the data generating mechanism. In addition to the constant variance assumption

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mans. This process is often the rate-limiting step in the elimination of a compound from the body and/or in the formation of active (reactive) metabolites. Large differences have been shown to occur between different species, and among different individuals within one species, in their capacity to o

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agents. The modern form of a drug delivery system should minimize side effects and reduce both dosage and dosage frequency. Nanoparticle drug delivery focuses on maximizing drug efficacy and minimizing cytotoxicity. Fine-tuning nanoparticle properties for effective drug delivery involves addressing

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is time has been spent following and, hopefully in some instances, contributing to advancement of the discipline of pharmacokinetics. During the last 40 years, pharmacokinetics has grown from a fledgling in the 1950s to an adult in the 1990s. The late development of the discipline of pharmacokinetic

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at has reached to provide drug concentration in the blood on and above the minimum effective concentration (MEC) upon its administration. The bioavailability is once again classified as absolute bioavailability and relative bioavailability. The ratio of the bioavailability of a drug administered by

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ical angiogenesis while minimizing damage to the neurosensory retina. This is perhaps best exemplified by the development of therapies targeting the potent angiogenic growth factor and vascular permeability mediator, vascular endothelial growth factor (VEGF). Anti-VEGF therapies, initially introduce

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ipheral nervous system of mammals regenerate spontaneously after injury..The relationships between neurons and nonneuronal cells are vital for the neuro’s maintenance and function. Trauma alters these relationships, causing nonneuronal cell proliferation, and in adult mammalian CNS creates an enviro