| 书目名称 | Tumor Suppressor Par-4 | | 副标题 | Structural Features, | | 编辑 | Vivek M. Rangnekar | | 视频video | | | 概述 | Highlights the structural features and molecular mechanisms of Par-4 function by global researchers.Provides researchers and clinicians with new insights into potential drug discovery and development | | 图书封面 |  | | 描述 | Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.. | | 出版日期 | Book 2022 | | 关键词 | prostate; par-4; apoptosis; cancer cells; protein; clinical trial; translational research; stem cells; PKA; T | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-73572-2 | | isbn_ebook | 978-3-030-73572-2 | | copyright | Springer Nature Switzerland AG 2022 |
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发表于 2025-3-21 17:52:23
