| 书目名称 | Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development |
| 编辑 | Constanze Bonifer,Peter N. Cockerill |
| 视频video | |
| 概述 | Translational aspect: describes how immune cell function is controlled and highlights human diseases where this is dysfunctional.From animal models to humans: Describes how more primitive organisms us |
| 丛书名称 | Epigenetics and Human Health |
| 图书封面 |  |
| 描述 | During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We |
| 出版日期 | Book 2014 |
| 关键词 | blood cell lineage development; epigenetic regulatory machinery; hematopoietic stem cells; immune defic |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-45198-0 |
| isbn_softcover | 978-3-662-51466-5 |
| isbn_ebook | 978-3-642-45198-0Series ISSN 2191-2262 Series E-ISSN 2191-2270 |
| issn_series | 2191-2262 |
| copyright | Springer-Verlag Berlin Heidelberg 2014 |
发表于 2025-3-21 18:39:20
