| 书目名称 | Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B |
| 编辑 | Xiao-Yu Sun |
| 视频video | |
| 概述 | Nominated by the Chinese University of Hong Kong as an outstanding PhD thesis.Novel and useful methodology for synthesizing highly substituted cyclic peroxides.Extends the field of Pd-catalyzed reacti |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery. |
| 出版日期 | Book 2012 |
| 关键词 | Springer Thesis Prize; biomimetic synthesis of plakortone B; cascade reaction; lipase-catalyzed kinetic |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-27195-3 |
| isbn_softcover | 978-3-642-44211-7 |
| isbn_ebook | 978-3-642-27195-3Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer-Verlag Berlin Heidelberg 2012 |
发表于 2025-3-21 17:05:42
