| 书目名称 | The Blood-Brain Barrier, Amino Acids and Peptides | | 编辑 | M. B. Segal,B. V. Zlokovic | | 视频video | http://file.papertrans.cn/906/905296/905296.mp4 | | 图书封面 |  | | 描述 | Definition of the barrier The interstitial fluid (rSF) of the brain is separated from the blood by the blood-brain barrier (BBB). This barrier must not be thought of as a single entity or as an absolute restriction to all molecules, but as a multiple structure located at several sites within the brain. The first of these interfaces is located at the endothelium of the brain capillaries. Secondly there is a potential site for interchange on the outer linings of the brain between the dura and the arachnoid membranes. Thirdly, there are the choroid plexuses and the cerebrospinal fluid (CSF) which is in contact with the very permeable internal ependymal lining of the brain (Figure 1. 1). Finally there are areas of the brain which lack a blood-brain barrier. These areas constitute the circumventricu lar organs and have leaky capillaries with a barrier at the ependyma which limits the spread of molecules from those regions (Figure 1. 2). Each of these BBB sites has its own characteristic permeability and transport functions. We will now consider the properties of each of these barrier sites between the blood and the brain. THE CEREBRAL CAPILLARY ENDOTHELIUM Morphology This interface has | | 出版日期 | Book 1990 | | 关键词 | blood; brain; interaction; proteins | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-009-2229-7 | | isbn_softcover | 978-94-010-7500-8 | | isbn_ebook | 978-94-009-2229-7 | | copyright | Kluwer Academic Publishers 1990 |
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