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Titlebook: Systems Theory in Immunology; Proceedings of the W Carlo Bruni,Gino Doria,Roberto Strom Conference proceedings 1979 Springer-Verlag Berlin

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Mechanism of B Lymphocyte Activationfic antibody synthesis. It was clear since long that interaction of antigen with Ig receptors alone could not be responsible for B cell activation, because two types of antigens existed; thymus-inde-pendent antigens that could directly activate B cells and thymus-dependent antigens that by themselve
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Clonal Dominance: Presentation of Antigenic Subsites is the Determining FactorB lymphocyte where antibody synthesis and secretion occur — the sum of many clonal responses, both specific and cross-reactive. Therefore, any study concerned with the expression of clones as well as with its products requires the separation of clones. This aim may be approached in several ways: a)
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Biological Variations of IgM Antibody Affinity(1), have been explained by the maturation theory (2). According to this theory, there are specific B lymphocytes with different receptor affinity prior to antigenic stimulation. Upon interaction of cell receptors with antigen the lymphocyte will proliferate and secrete antibodies with the same affi
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