Titlebook: Systems Metabolic Engineering; Christoph Wittmann,Sang Yup Lee Book 2012 Springer Science+Business Media Dordrecht 2012 In Silico Design o

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Systems Metabolic Engineering of , for Chemicals, Materials, Biofuels, and Pharmaceuticals,ate materials. Recent advances in these fields have opened a new way of metabolic engineering, termed systems metabolic engineering. In this article, we review the achievements in systems metabolic engineering for the production of chemical compounds and materials, biofuels, and pharmaceuticals in a widely used microbial platform factory, ..

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Kinetic Modeling of Metabolic Networks,oteomics profiles in high throughput may soon make accurate kinetic models of metabolism a reality. In this chapter, we review theoretical concepts useful for developing kinetic models of metabolism, practical difficulties with constructing such models, and methods that have been developed in an effort to circumvent these difficulties.

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Design of Superior Cell Factories Based on Systems Wide Omics Analysis,hes to narrow the selection of promising candidate genes as targets for higher productivity. In this chapter, we review several studies that demonstrate successful breeding based on omics data, and discuss how we can design experiments and screen for target genes to be manipulated for the development of superior cell factories.

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Kinetic Modeling of Metabolic Networks,y metabolic response to perturbation at timescales before a steady state is reached, however, a more explicit kinetic model must be developed. While kinetic models of metabolism have been around for longer than their stoichiometric counterparts, progress towards practical and useful kinetics models

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Technologies for Biosystems Engineering,evelopment and biological systems behavior drives an engineering effort to design and construct ever more complex novel molecular or cellular functions and behaviors. As molecular functions are encoded on DNA level, engineering of new and complex systems starts with the engineering of its encoding D

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