Titlebook: Systems Genetics; Methods and Protocol Klaus Schughart,Robert W. Williams Book 2017 Springer Science+Business Media New York 2017 Mendelian

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Systems Genetics978-1-4939-6427-7Series ISSN 1064-3745 Series E-ISSN 1940-6029

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QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzentraits. Here, we provide a case study in which male DO mice were exposed to benzene and phenotyped for the number of micronucleated reticulocytes. We provide step-by-step R scripts for the analysis of phenotypes, genotypes, mapping of resistance gene loci and identification of candidate genes.

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1064-3745 ation advice from the experts.Includes supplementary materia.This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease—what is now often called personalized or precision health care.

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Epigenetics and Control of RNAsc, describe in detail how ChIP-seq data are analyzed and elaborate on how to integrate ChIP-seq and RNA-seq data from a segregating disease animal model for the identification of the epigenetic control of RNA expression.

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RNA-Seq in the Collaborative Crossrom collaborative cross studies, as the genomes across individual strains differ considerably. In this chapter we will provide an overview of how to effectively perform RNA-seq analysis from data obtained from the CC mice.

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Resources for Systems Geneticsxed populations such as the Collaborative Cross and Diversity Outcross to relatively simple crosses such as sets of consomic strains and reduced complexity crosses. This protocol is intended to help investigators make more informed decisions about choices of resources given different types of questi

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Heterogeneous Stock Populations for Analysis of Complex Traitsding together eight inbred strains, followed by maintaining the colony in a manner that minimizes inbreeding. After 50 or more generations of breeding, the resulting animals’ chromosomes represent a genetic mosaic of the founders’ haplotypes, with the average distance between recombination events in

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