Titlebook: Systemic Vasculitides: Current Status and Perspectives; Franco Dammacco,Domenico Ribatti,Angelo Vacca Book 2016 Springer International Pub

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Animal Models of ANCA-Associated Vasculitidestiology and pathogenetic mechanism(s) are still poorly understood. The establishment of experimental models has been repeatedly attempted with the aim of achieving a deeper understanding of their human counterpart. Here, we discuss the principal animal models currently used to investigate the mechanisms underlying the onset of AAV.

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Anti-Glomerular Basement Membrane Diseaselveolar hemorrhage that may be life threatening when massive. Diagnosis rely on recognition of anti-GBM antibodies at tissue level (often kidneys) and/or in the blood. Treatment is based on plasma exchange in order to remove autoantibodies from circulation and on immunosuppressive agents in order to reduce antibodies production.

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Giant Cell Arteritisglucocorticosteroids for several years. Adverse events of glucocorticosteroids affect more than 50 % of patients. Trials of steroid-sparing drugs have yielded conflicting results. The understanding of the molecular mechanisms involved in the pathogenesis of GCA recently has indicated new targets for therapy.

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