Titlebook: Syringomyelia; A Disorder of CSF Ci Graham Flint,Clare Rusbridge Book 20141st edition Springer-Verlag Berlin Heidelberg 2014 Cerebrospinal

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Veterinary Aspects,both syringomyelia and central neuropathic pain, observations that may have relevance to understanding of the pathophysiology of Chiari malformation and syringomyelia in humans are discussed. Finally, current knowledge of genetic factors and breeding advice is reviewed.

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Epidemiology,d idiopathic syringomyelia. The clinical course of the disease, age at presentation, prevalence of symptomatic versus asymptomatic patients, life expectancy, mortality and inheritance of Chiari malformation are also discussed.

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Developmental Anatomy,s particular focus on developmental anomalies of the craniocervical junction and the embryology of the Chiari malformations, including prenatal diagnosis and the role of foetal surgery for Chiari II malformation.

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Genetics of Chiari Malformation and Syringomyelia,c syndromes. Molecular studies of Chiari in humans are reviewed, including candidate gene studies and linkage studies. Finally, canine models for Chiari and syringomyelia and likely future studies are detailed.

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