Titlebook: Synthetic Biology; Omics Tools and Thei Shailza Singh Book 2018 Springer Nature Singapore Pte Ltd. 2018 synthetic biology.omics.systems bio

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Synthetic Probes, Their Applications and Designing, for their maximal potential. A number of tools are available for probe designing for various applications. This chapter focuses on the natural and artificial nucleic acid probes, the differences in the chemistry of these probes, their advantages, limitations and synthetic applications along with so

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Omics-Based Nanomedicine,, disease management, and prognosis as well as individualized drug selection by reducing side effects and cytotoxicity. In this book chapter, we have discussed about the leading technologies available for personalized nanomedicine and immense potential combination of nanomedicine with high-throughpu

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Integrated Systems and Chemical Biology Approach for Targeted Therapies,yed an enormous role in dealing with the inherent complexity of the biological system whether be metabolic, signaling, or transcriptional network. In this chapter, methods have been discussed for elucidating the mathematical networks underlying different diseases and thereby identifying the key comp

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Integrative Omics for Interactomes,gical process. The integrative omics approach has been initially applied to cancer research and later used in understanding host-pathogen interactions and pluripotency regulatory networks in stem cells. Here, different multi-omics layers along with databases and tools specific for multiple data inte

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Studying Parasite Gene Function and Interaction Through Ribozymes and Riboswitches Design Mechanisms biological processes via utilizing their secondary structure and consist of two distinct regions: (i) an evolutionarily conserved ligand-binding aptamer region and (ii) a variable expression platform regulating the gene expression. Many ligands bind to riboswitches, and its accurate and selective

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Genome Microbiology for Synthetic Applications,nto the natural cellular phenomena and thus is implicated for a variety of applications. A key step in synthetic biology is logical combination of simple circuits into higher-order systems which work like a genetic switchboard which is subsequently implicated in building novel biological entities on

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Medicinal Application of Synthetic Biology, is an emerging approach of medicinal science which is now on the edge of creating a novel life with potential and effective functions at genetic level. It represents the responsibility of engineering into the biological science to redesign the new biological system that doesn’t exist in the nature.

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Computational Tools for Applying Multi-level Models to Synthetic Biology,thetic Biology design cycle benefits from the understanding and the proper representation of the underling biological complexity, allowing predicting the behavior of the target system. Considering the intrinsic nature of the systems to be designed with a Systems Biology perspective is a key requirem

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Computational Techniques for a Comprehensive Understanding of Different Genotype-Phenotype Factors techniques are widely used to extract some meaningful information from the underlying heterogeneous, raw biological data. Here, we review the use of different approaches to mathematically model biological data at different levels of complexities. At the raw sequence level, we discuss about the vario