Titlebook: Synthesis of Therapeutic Oligonucleotides; Satoshi Obika,Mitsuo Sekine Book 2018 Springer Nature Singapore Pte Ltd. 2018 Therapeutic oligo

expansive

Non-protected Synthesis of Oligonucleotides–N bond cleavage using 6-nitro-HOBt is more than 99% in the RNA synthesis without base protection. In this review, we summarize the .-selective phosphorylation in DNA and RNA synthesis without base protection and the synthesis of modified oligonucleotides having alkaline-labile functional groups using these new methods.

Indebted

荣幸

Book 2018tic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of

可以任性

Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modifiede physicochemical properties of thio-modified bases and the methods for the syntheses of 2-thiouridine and 2-thiothymidine are described. In addition, the solid-phase synthesis of oligonucleotides incorporating these thio-nucleosides is described.

Accolade

Site-Specific Modification of Nucleobases in Oligonucleotides, the site-specific modifications focusing on nucleobases within oligonucleotides are summarized. Moreover, as an experimental example of site-specific modification of an oligonucleotide, the preparation of .,.-disubstituted cytosine derivatives using reaction of 4-triazolylpyrimidin-2-one nucleobase with various secondary amines is demonstrated.

demote

Cholesterol

MIRE

Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modiith their complementary nucleic acid within a few seconds of photoirradiation are examined. The details of the synthetic method, properties and the applications for regulating gene expression in cells are discussed.

Affirm

都相信我的话

and inspire fresh ideas in nucleic acid chemistry.Meets the .This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous