Titlebook: Superantigens; Bernhard Fleischer,Hans Olov Sjögren Book 1991 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Toxic Shock Syndrome Toxin-1, Toxic Shock, and the Immune System,in, and dysfunction of multiple organ systems (. 1989; . et al. 1980; . et al. 1978). TSS is consistently associated with infection by toxigenic strains of ., most commonly in the setting of tampon use during menses or following surgery or trauma. Exotoxins secreted by staphylococcal isolates from p

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Staphylococcal Enterotoxin-Dependent Cell-Mediated Cytotoxicity,nse against bacteria is mainly constituted of mechanical barriers, such as intact epithelial membranes, and nonspecific immune mechanisms, for example granulocytes and macrophages. Bacteria generally cause disease when these barriers are overridden. It has recently become increasingly clear, however

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MUT

GENRE

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The Immunobiology of , and its Superantigen MAM,. and . 1988) and by inducing polyclonal B cell activation leading to the production of autoantibodies (. et al. 1990). Of special interest is the superantigen MAM (. T cell mitogen) which is produced by a microorganism that is known to cause a chronic relapsing arthritis in rodents.

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Ornithologist

crease

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,Molecular Genetics of Pyrogenic Exotoxin “Superantigens” of Group A Streptococci and ,, elaboration by the microbe of toxins which induce disease manifestations. In this example the pathogen must only be able to survive and multiply within the host for a sufficient period of time to make the toxin. Toxin-host cell receptor interactions then determine the extent of host tissue damage.