| 书目名称 | Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies |
| 编辑 | Yunchen Bi |
| 视频video | |
| 概述 | Nominated as a distinguished doctoral dissertation by the Chinese Academy of Sciences.Studies the calcium regulation mechanism of T cell receptor (TCR) activation by combining biophysical (mainly nucl |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.. |
| 出版日期 | Book 2018 |
| 关键词 | Calcium regulation; Dengue virus; NMR; Nanodisc technology; Nuclear magnetic resonance; Protein-lipid int |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-662-54618-5 |
| isbn_softcover | 978-3-662-57206-1 |
| isbn_ebook | 978-3-662-54618-5Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer-Verlag GmbH Germany 2018 |
发表于 2025-3-21 17:17:16
