Titlebook: Studies on Experimental Toxicology and Pharmacology; Stephen M. Roberts,James P. Kehrer,Lars-Oliver Klo Book 2015 Springer International P

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Georgia K. Hinkley,Stephen M. Robertslity problems. For example, researchers that study Life Sciences datasets to explain phenomena or identify anomalies, demand that their findings correspond to current discoveries, and not to the effect of low data quality standards of completeness or redundancy. In this paper we propose LiQuate, a s

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Lars-Oliver Klotzwe expect that the effective use of classical text mining techniques can cluster a set of workflows in families, offering to the scientists the possibility of finding and reusing existing workflows, which may decrease the complexity of modeling a new experiment. This paper presents Athena, a cloud-b

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An Overview of Free Radicals as Causes and Consequences of Toxicitynts. Through the numerous studies performed, it has become apparent that changes in the cellular redox state are responsible for some of the adverse effects resulting from exposures to both natural and man-made drugs and chemicals. At the same time, it has also become apparent that the oxidative dam

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Lipid Oxidationipid oxidation products. Mechanistic explanations are provided for the diverse biological effects of lipid oxidation products that range from deleterious to regulatory and even to protective. Finally, analytical techniques used for detection of lipid oxidation and lipid oxidation products are discus

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Protein Oxidation in Toxicologyined as oxidative stress. A variety of consequences result from oxidative damage of proteins. For example, key proteins of metabolism and signal transduction may be impaired either by direct damage of their active sites or by partial unfolding. Many oxidative protein modifications are irreversible,

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Oxidative Stress and DNA Damage Association with Carcinogenesis: A Truth or a Myth?resulting in various outcomes for the cell such as loss of function and stability, mutation, senescence (mainly due to telomeric shortening) and/or cell death, unless removed rapidly by antioxidative mechanisms evolved by the cell. Over the last decade, great emphasis has been put on the potential r