Titlebook: Stroke Genomics; Methods and Reviews Simon J. Read,David Virley Book 2005 Humana Press 2005 Chromosom.PCR.gene expression.gene therapy.gene

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3-Nitropropionic Acid Model of Metabolic Stressia, carbon monoxide poisoning, and hypoglycemia. Here we describe a method to produce 3-NPA-induced lesions using the systemically administered toxin. We also describe magnetic resonance imaging methods to allow assessment of lesion severity over time within the same animal.

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Bioinformatic Approaches to Assigning Protein Function From Novel Sequence Data clues, most of unassigned sequences can now be annotated. This chapter takes as an example an unannotated expressed sequence tag, describing how to identify its related gene, and how to annotate the encoded protein using sequence, profile, and structure-based annotation methodologies.

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Choice, Methodology, and Characterization of Focal Ischemic Stroke Modelscal stroke models is required to provide confidence in predicting therapeutic efficacy. Compelling evidence for novel therapies derived from the pathological and functional consequences of models of cerebral ischemia in the rat (and higher species) is an essential prerequisite before large expensive

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Mutant Animal Models of Stroke and Gene Expressionwith particular diseases. However, using human DNA to correlate individual genomic variations with particular disorders such as stroke will be extremely challenging because of the large number of variables within an individual, and across different populations. Mutant animal models of stroke such as

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Gene Therapy in Neurological Diseasetion. The use of modified viral vectors has now made it possible to introduce foreign DNA into central nervous system cells, permitting overexpression of the protein of interest. A particular advantage of the herpes simplex system is that the herpes virus is neurotropic and is therefore suited for g

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Stem Cell Transplantation After Middle Cerebral Artery Occlusionof damage and to differentiate into neurons and glia. Grafts of murine stem cells have been shown to promote recovery from behavioral dysfunction after stroke. We have developed protocols to optimize behavioral testing, animal recovery, and stem cell delivery after middle cerebral artery occlusion.

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