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Titlebook: Stroke Genetics; Pankaj Sharma,James F Meschia Book 20131st edition Springer-Verlag London 2013 CADASIL.Fabry.GWAS.Genetics.Genome.Hyperte

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发表于 2025-3-21 16:17:30 | 显示全部楼层 |阅读模式
书目名称Stroke Genetics
编辑Pankaj Sharma,James F Meschia
视频video
概述Summarizes the current state of knowledge in stroke genetics, using stroke as a paradigm in understanding other complex disorders thereby providing a single authoritative source on the molecular basis
图书封面Titlebook: Stroke Genetics;  Pankaj Sharma,James F Meschia Book 20131st edition Springer-Verlag London 2013 CADASIL.Fabry.GWAS.Genetics.Genome.Hyperte
描述.Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. .Stroke Genetics. is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. . .Stroke Genetics. benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. .Stroke Genetics. is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics..
出版日期Book 20131st edition
关键词CADASIL; Fabry; GWAS; Genetics; Genome; Hypertension; MELAS; Stem Cell; Stroke; cerebral hemmorhage
版次1
doihttps://doi.org/10.1007/978-0-85729-209-4
isbn_softcover978-1-4471-6176-9
isbn_ebook978-0-85729-209-4
copyrightSpringer-Verlag London 2013
The information of publication is updating

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发表于 2025-3-21 21:37:40 | 显示全部楼层
Introduction,This chapter briefly describes the background evidence of why stroke has an inherited component and places it in context with other common disorders. It goes on to suggest ways of managing inherited stroke conditions in the general clinic.
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Genome-Wide Association Studies (GWAS),Genome-wide association studies (GWAS) have revolutionized our understanding of common diseases at the molecular level. This chapter discusses these strategies and describes key recent successes in stroke.
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Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy,Genetic variation appears to play a substantial role in sporadic intracerebral hemorrhage. In addition to offering the promise of desperately needed preventative treatments, identification of the culprit variants may prove useful in screening individuals for long-term anticoagulation.
发表于 2025-3-22 19:39:59 | 显示全部楼层
Clinicogenetic and Pathologic Characteristics of CADASIL,CADASIL is the most common inherited monogenic disorder causing stroke. It is becoming increasingly recognized across many ancestral groups. This chapter presents the salient features of the disorder to assist those unfamiliar with CADASIL to recognize the disorder.
发表于 2025-3-22 23:52:58 | 显示全部楼层
Monogenic Disorder: Fabry Disease,Fabry disease is a rare inborn error of metabolism, which causes a number of neurological disorders including stroke. This chapter summarizes our current understanding of this condition at the molecular level and addresses treatment strategies.
发表于 2025-3-23 03:54:47 | 显示全部楼层
Genetics of Sickle Cell Disease and Stroke,Sickle cell disease is a common worldwide disorder that can lead to stroke in affected individuals. This chapter describes the epidemiology, pathophysiology, and genetics that contribute to the onset of this disorder. Evidence-based treatment recommendations are also given.
发表于 2025-3-23 07:02:56 | 显示全部楼层
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