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Titlebook: Stereoselective Syntheses of Tetrahydropyrans; Applications to the Kiyoun Lee Book 2014 Springer International Publishing Switzerland 2014

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发表于 2025-3-21 19:50:40 | 显示全部楼层 |阅读模式
书目名称Stereoselective Syntheses of Tetrahydropyrans
副标题Applications to the
编辑Kiyoun Lee
视频video
概述Nominated as an outstanding Ph.D. thesis by Duke University, USA.Pursues a clearly structured and easy-to-follow methodology.Provides straightforward figures of target molecules.Includes easy-to-find
丛书名称Springer Theses
图书封面Titlebook: Stereoselective Syntheses of Tetrahydropyrans; Applications to the  Kiyoun Lee Book 2014 Springer International Publishing Switzerland 2014
描述In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
出版日期Book 2014
关键词(+)-Dactylolide; (+)-Leucascandrolide A; (±)-Diospongin A; Gem-disubstituent Effect; Tandem Cross-metath
版次1
doihttps://doi.org/10.1007/978-3-319-04462-0
isbn_softcover978-3-319-35675-4
isbn_ebook978-3-319-04462-0Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer International Publishing Switzerland 2014
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发表于 2025-3-21 22:04:03 | 显示全部楼层
Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Additione addition of carbon nucleophiles to many different types of Michael acceptors [.]. However, the analogous conjugate additions of other heteroatom nucleophiles such as amines, thiols, phosphines, and alcohols have not progressed at the same rate [.–.]. This is especially true for the application of
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,Synthesis of 4-Hydroxy-2,6-,-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal S,2′ Reaction,hemical operation [.–.]. Hence, the development of tandem reactions is a rapidly growing area in the realm of synthetic organic chemistry [.–.]. Tandem processes offer a powerful approach for conveniently accessing more complex architectures and permit efficient access to unique chemical structures
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,Synthesis of 4-Hydroxy-2,6-,-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal S,2′ Reaction,.]. The main advantages of tandem reactions are the reduction in overall steps by avoiding isolation of often highly reactive intermediates, minimal use of protecting groups, and the environmental benefits by saving time and reducing waste.
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