Titlebook: Stem Cells in the Lung; Development, Repair Ivan Bertoncello Book 2015 Springer International Publishing Switzerland 2015 bronchiolar airw

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Stem and Progenitor Cells of the Trachea and Proximal Airwayshma, cystic fibrosis, and lung cancer. Understanding the proximal airway epithelium, its stem cell subpopulations, its development, its niche, and the mechanisms regulating its repair are all critical for ultimately developing novel therapies for airway diseases.

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Stem Cells of the Distal Bronchiolar Airwayslate stem cells within their local niche and address the contribution of bronchiolar stem cells to chronic lung diseases including cancer. An increased understanding of these cells and the mechanisms underlying their function and dysfunction will facilitate the development of novel cellular and small molecule therapies for improving human health.

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Epithelial–Mesenchymal Crosstalk in Lung Developmentc organization of the bronchial epithelial tree and subsequently, although not discussed in detail here, the alveoli. Within the mesenchyme, correct organization and function of the capillaries and nerves is likewise essential to achieve a fully functional lung. Molecular mechanisms of these interactions are discussed.

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Extracellular Matrix Specification of Regenerative Cells in the Adult Lungd thereby possibly contributing to disease pathologies. The use of the ECM from decellularised tissue as a scaffold for regenerating a healthy lung for transplantation purposes is an exciting and challenging new frontier in ECM biology.

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