Titlebook: Stem Cells in the Lung; Development, Repair Ivan Bertoncello Book 2015 Springer International Publishing Switzerland 2015 bronchiolar airw

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Lung Vasculogenesis and Angiogenesise lung passively follows that of the airways. Rather, lung blood vessels actively promote alveolar growth during development and contribute to the maintenance of alveolar structures throughout postnatal life. These observations may be relevant for lung diseases characterized by arrested alveolar gro

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Neural Regulation of Lung Developmentlife. During early embryonic development, the lung primordium, originating from the ventral foregut endoderm, bifurcates ventrolaterally to form two primary lung buds. Within these developing buds, the lung mesoderm interacts with the endoderm to generate various lineages, including airway smooth mu

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Fetal and Neonatal Origins of Lung Diseasenducting airways, is especially vulnerable. Owing to a limited capacity for repair, the functional effects of lung injury or altered development during fetal or early postnatal life may persist into later life, affecting lung function and disease vulnerability. A range of environmental factors can l

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Stem and Progenitor Cells of the Trachea and Proximal Airwaysjured by exposure to toxins and microbials from the environment, but it has an efficient repair mechanism originating from its endogenous stem cells. However, with chronic injury, this repair process can go awry and result in several airway diseases such as chronic obstructive pulmonary disease, ast

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Stem Cells of the Distal Bronchiolar Airwayschi, bronchiolar airways, and alveoli. Here, we discuss the identity and molecular properties of stem cells in the distal bronchioles and describe their contribution to conducting airway homeostasis, repair, and lung regeneration. We assess the role of extrinsic, microenvironmental factors that regu

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Regenerative Cells in the Ageing Lungg. Further, ageing alters the biological responses of the lung to injury, infection, and tissue resection. Regeneration of the lung can be reactivated by partial pneumonectomy (PNX), thus making PNX a unique and powerful model for the analysis of age-dependent regenerative mechanisms in the healthy

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Extracellular Matrix Specification of Regenerative Cells in the Adult Lungell progenitor pools required for lung regeneration and repair. The meshwork of proteins that comprise the ECM not only provide structural support and rigidity, but also regulate cellular activities within the tissue microenvironment by virtue of the composition and stiffness of the ECM to which the

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Role of Mechanical Stress in Lung Repair and Regenerationnsatory lung growth and remodeling following major loss of lung units, leading to partial to complete restoration of normal structural dimensions and function. The threshold, optimal range, and upper limit of mechanically induced adaptation have been characterized in a pneumonectomy model, and two i