Titlebook: Stem Cell Biology in Health and Disease; Thomas Dittmar,Kurt S. Zanker Book 2010 Springer Science+Business Media B.V. 2010 Stem Cell.Vivo.

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Hematopoietic Stem and Progenitor Cells in Clinical Use – Transplantation and Mobilization versus steady state bone marrow is challenging not only for transplant physicians but also for the donors..This chapter provides an overview about the history of stem cell transplantation, current procedures and future developments in terms of donor selection and graft choices for hematopoietic ste

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Alternative Embryonic Stem Cell Sourcesf laboratories. Here we review the tremendous progress made in recent years in this very dynamic area of research and discuss implications that these new developments may have for biomedical research and regenerative medicine in near future.

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Transplantation of Stem Cells and Their Derivatives in the Treatment of Multiple Sclerosis are still ongoing to determine whether stem cell-derived precursor cells are capable of myelinating axons in animal models of MS, an important step in demonstrating the therapeutic potential of transplanted cells in MS. In addition, the method of cell delivery to patients and the selection of MS pa

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Cancer: A Stem Cell-based Disease? to divide asymmetrically will lead to teratomas, whereas the stable irreversible alteration of an adult stem cell’s ability to proliferate asymmetrically will lead carcinomas and sarcomas. An attempt will be made to integrate the (a) multi-stage/multi-mechanism hypothesis; (b) mutation/epigenetic t

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Leukemia Stem Cellsiation of leukemia at its onset. They also represent the rare leukemia cell population that gives rise to relapse and drug-resistance of the disease in patients. Here, current data on the cellular origin, phenotype and central signaling pathways of self-renewal in acute myeloid leukemia (AML), chron

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“One for All” or “All for One”? – The Necessity of Cancer Stem Cell Diversity in Metastasis Formatioten more aggressive than the original tumor. This suggest the necessity and existence of different CSC subtypes. In the present chapter, we will discuss whether different, cancer stage specific CSCs exist and if, how these particular cell types might originate.