Titlebook: Squamous cell Carcinoma; Molecular Therapeuti Saman Warnakulasuriya,Zakir Khan Book 2017 Springer Science+Business Media B.V. 2017 Squamous

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,Cancer Stem Cells—Biopathology with Reference to Head and Neck Cancers, specific markers to identify SCs and CSCs in tissues and to determine topographic relationships with their lineage. This chapter provides an update on the literature related to stem cells and oral cancer, centering on the CSC hypothesis in this context and on progress in the identification of oral stem cells.

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Hypoxia in Head and Neck Cancer,us of studies to improve treatment response for many years. This chapter aims to discuss some of the key mechanisms affected by tumour hypoxia and review strategies under investigation towards better detection and modulation of tumour hypoxia in order to improve treatment response and survival of head and neck cancer patients.

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MicroRNA: Utility as Biomarkers and Therapeutic Targets in Squamous Cell Carcinoma,y represent viable therapeutic targets. This chapter will summarise the current knowledge of microRNA expression changes in head and neck squamous cell carcinomas and give an overview of the translational opportunities they currently offer.

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,Survivin as a Therapeutic Target in Squamous Cell Carcinoma, cancer diagnosis and a promising therapeutic target. Disruption of the survivin induction pathway has resulted in an increase in apoptosis and inhibition of tumor growth. In this chapter, we will discuss recent advances in cancer therapeutics targeting survivin gene.

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FUSC

Hypoxia in Head and Neck Cancer,% (Suh et al. .). Over 90% are squamous cell carcinomas arising from the epithelial cells that line the mucosal surfaces of the head and neck. Tumour hypoxia is an important negative prognostic factor for head and neck squamous cell carcinomas (HNSCC), associated with resistance to radiotherapy and

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