| 书目名称 | Somatostatin | | 编辑 | Coimbatore B. Srikant | | 视频video | | | 概述 | Since the discovery of somatostatin barely 30 years ago, the mechanism of action of this ubiquitous peptide has been rigorously investigated..This volume contains a comprehensive tour de force of adva | | 丛书名称 | Endocrine Updates | | 图书封面 |  | | 描述 | Thirty years have passed since somatostatin was discovered and its hormonal function defined [1,2]. The wide range of anatomical distribution and actions of somatostatin and its receptors stimulated intense scientific and clinical interest, and fostered extensive research into all aspects of its biology including regulation of its gene expression, processing of its precursor, biological and cellular actions relating to regulation cell secretion, motility and proliferation. The development of metabolically stable peptide analogs helped define its usefulness in the treatment of endocrine diseases and cancer. The heterogeneity of somatostatin receptors recognized in 1981 [3] was later shown to result from the existence and variable expression of five distinct subtypes that constitutes two distinct subfamilies with distinguishing pharmacological characteristics [4,5]. The molecular cloning of these receptor subtypes reignited the interest in this field leading to a major increase in our insight into the biology of somatostatin and its receptor subtypes, and has led to the design and development of subtype-selective peptide and non-peptide agonists and antagonists. Significant progress | | 出版日期 | Textbook 2004 | | 关键词 | apoptosis; biology; cancer; cell; genetics; hormones; imaging; physiology; research; tissue | | 版次 | 1 | | doi | https://doi.org/10.1007/b112847 | | isbn_softcover | 978-1-4419-5440-4 | | isbn_ebook | 978-1-4020-8033-3Series ISSN 1566-0729 | | issn_series | 1566-0729 | | copyright | Springer Science+Business Media New York 2004 |
The information of publication is updating
|
|
发表于 2025-3-21 19:41:50
