| 书目名称 | Solving a 3D Structural Puzzle |
| 编辑 | Casper Rønn Hoeck |
| 视频video | |
| 概述 | Nominated as an outstanding Ph. D. thesis by the Technical University of Denmark.Expands the structural knowledge of organic and natural compounds using NMR spectroscopy.Outlines novel NMR experimenta |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This book explores how nuclear magnetic resonance (NMR) spectroscopy may be used for spatial structural elucidation of novel compounds from fungal and synthetic sources. Readers will discover the exciting world of NOE (nuclear Overhauser effect), RDC (residual dipolar coupling) and J-coupling constants, both short- and long range. With emphasis on obtaining structural knowledge from these NMR observables, focus is moved from solving a static 3D structure to solving the structural space inhabited by small organic molecules..The book outlines the development and implementation of two Heteronuclear Multiple Bond Correlation-type NMR experiments, and the 3D structural elucidation of multiple known and novel compounds. In addition, a new method of back-calculating RDCs (allowing for more flexible structures to be investigated), and the synthesis and evaluation of novel chiral alignment media for ab initio determination of absolute stereochemistry of small molecules using RDCs are also included. Challenges that 3D structural generation of small compounds face are also covered in this work.. |
| 出版日期 | Book 2018 |
| 关键词 | NMR; Nuclear Overhauser Effect; Residual Dipolar Coupling; J-coupling Constants; Long Range Coupling Con |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-96172-9 |
| isbn_ebook | 978-3-319-96172-9Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Switzerland AG 2018 |
发表于 2025-3-21 16:25:51
