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Titlebook: Slow Virus Infections of the Central Nervous System; Investigational Appr Volker Meulen,Michael Katz Conference proceedings 1977 Springer S

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楼主: ODDS
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Comment/Chapter 3 budding virus and the complete virus (Fig. 3A.1). The buds are almost twice the size of the complete virus. Serial sections reveal occasionally a cross-sectional view of the buds, which may falsely appear as detached virus. In reality, however, the majority of particles are not detached and we have
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Discussion/Chapters 4–5t incubation period. Dr. Ludwig replied that it was the persistence of the virus and antibodies against it and the localization of the infection to one organ system that made it comparable to the slow virus infections. Furthermore, in the natural infection of horses, the incubation period seems to b
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Progressive Multifocal Leukoencephalopathyocytes by papovaviruses. The pathology and pathogenesis of PML are distinct from those of the other slow infections of the human nervous system. Kuru and Creutzfeldt-Jakob disease appear to be caused by obligate “slow viruses” that produce noninflammatory degenerative disease in primate brains and t
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Discussion/Chapter 6cases of the same disease. Dr. Johnson replied that he had no hypothesis, but noted that the two patients with SV40-PML did not have neoplasms. Both were immunosuppressed—one because of therapy for lupus erythematosus and the other because of some inborn defect of the immune system. Of the other 12,
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Comment/Chapter 6the papova-viruses etiologically involved? If so, how many cases are due to SV40, how many to JC virus (JCV), and how many, if any, to BK virus (BKV)? The answer can only come from continued study of cases of PML, but unfortunately they are relatively rare, and it is difficult to get the tissues bef
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Subacute Sclerosing Panencephalitise classic description of this disease are Dawson (13) and van Bogaert (7). Clinically, the condition begins with subtle intellectual deterioration, with a gradual appearance of incoordination and other motor abnormalities, proceeding to myoclonic jerks, sustained myoclonus, coma, and death. The cour
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