Titlebook: Skin Stress Response Pathways; Environmental Factor Georg T. Wondrak Book 2016 Springer International Publishing Switzerland 2016 skin barr

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Nitric Oxide Derivatives and Skin Environmental Exposure to Light: From Molecular Pathways to Therac oxide synthase (NOS)-expression in human skin tissue in. Already in the first years on NO research it became obvious that NO plays a pivotal role in the dermal response to environmental stimuli like ultraviolet radiation, heat, and cold. Additionally to enzymatically produced NO a range of non-enz

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TLR3 and Inflammatory Skin Diseases: From Environmental Factors to Molecular Opportunities,rn produced by most viruses. Interestingly, there is increasing recognition of the role of TLR3 in non-infectious inflammatory diseases as well as viral infections. In addition, TLR3 recognizes not only exogenous threats such as virus but also endogenous host molecules associated with tissue injury.

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Sirtuins and Stress Response in Skin Cancer, Aging, and Barrier Function,s and ADP ribosyltransferases. Sirtuins regulate numerous pathways in metabolism, aging and cancer. They are critical modulators in the cellular response to metabolic, oxidative, or genotoxic stress. Recent advances have demonstrated the pivotal role of sirtuin proteins in aging and a wide range of

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Regulation of Cutaneous Stress Response Pathways by the Circadian Clock: From Molecular Pathways tos. Our environment is highly dynamic, with robust time-of-day dependent fluctuations in temperature, solar radiation, and probability of injury and infections. In addition, oxidative metabolism and cell-cycle progression in epidermal stem cells show prominent diurnal rhythms. Accumulating evidence s

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