Titlebook: Single-Cell-Based Models in Biology and Medicine; Alexander R. A. Anderson,Mark A. J. Chaplain,Katar Book 2007 Birkhäuser Basel 2007 Singl

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A 3-D Deformable Ellipsoidal Cell Model with Cell Adhesion and Signalingifferentiation all work together in a coordinated fashion to give rise to the developed organism. The . is used as a model system, since it is simple, yet has all the basic cell-cell interactions. Another goal of introducing this model is to achieve visualization of cell movements and signal propaga

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Center-based Single-cell Models: An Approach to Multi-cellular Organization Based on a Conceptual Anation results for in-vitro systems and discuss the effect of model variants on simulated multi-cellular growth phenomena. The aim of this chapter is to provide an introduction and overview of the algorithms, technical concepts and the framework necessary to perform equivalent computational simulations with different model variants.

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The Cellular Potts Model and Biophysical Properties of Cells, Tissues and Morphogenesisthose mappings that the modelling formalism is a powerful tool for investigating a large range of biological questions, from those concerning biophysical properties of single cells, cell motion, tissue level properties, all the way up to understanding the full morphogenesis and life-cycle of an organism.

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Modelling the Development of Complex Tissues Using Individual Viscoelastic Cellshree applications of this model are presented: the folding of a trophoblast bilayer, clonal tumoural growth and self-arrangement into a hollow acinus, the hollow multicellular sphere. Further extensions of this model are also discussed.