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Titlebook: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles; Henry Jay Forman,Jon Fukuto,Martine Torres

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发表于 2025-3-21 16:42:23 | 显示全部楼层 |阅读模式
书目名称Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
编辑Henry Jay Forman,Jon Fukuto,Martine Torres
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图书封面Titlebook: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles;  Henry Jay Forman,Jon Fukuto,Martine Torres
描述Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those mo
出版日期Book 2003
关键词Activation; Drogen; Regulation; biochemistry; biosynthesis; conservation; enzymes; gene expression; genes; hy
版次1
doihttps://doi.org/10.1007/0-306-48412-9
isbn_softcover978-90-481-6216-1
isbn_ebook978-0-306-48412-4
copyrightSpringer Science+Business Media Dordrecht 2003
The information of publication is updating

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发表于 2025-3-21 21:36:24 | 显示全部楼层
4-Hydroxynonenal Signalingups. As far as exogenous HNE is concerned, this could either be somehow taken up by the cell or signal from the cell surface by activation of EGF and/or EGF-like receptors. The high interest more recently earned by HNE signaling will probably lead to rapid clarification also of the upstream biochemical pathway/s triggered by the aldehyde.
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" -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulat
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Map Kinases in Redox Signaling pathways. Cells determine their fate, such as survival, differentiation and apoptosis, by cross talk between the redox state and the intracellular signaling systems, especially the MAPK cascades. Further studies are necessary to understand the mechanism by which the redox state regulates cell signaling at the molecular level.
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NO Synthesis and NOS Regulationhey usually show a constitutive, basal expression, which however, can be modified by various agents and conditions. In addition to the intracellular Ca. level, post-translational modifications and the subcellular targeting of these enzymes determine their activity. iNOS is a high output enzyme that
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Hydrogen Peroxide as Intracellular Messenger: Identification of Protein Tyrosine Phosphatases and Pth oxidation of their essential Cys residues. This model suggests that the receptor-mediated activation of RTK and PI 3-kinase may not be sufficient for the accumulation of tyrosine phosphorylated proteins and 3′-phosphorylated PIs because of the opposing activity of PTPs and PTEN, respectively. The
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