Titlebook: Scleroderma; From Pathogenesis to John Varga,Christopher P. Denton,Masataka Kuwana Book 20172nd edition Springer Science+Business Media New

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des new chapters on personalized medicine, cancer complicati.Comprised of the authoritative work of international experts, this fully-updated second edition of .Scleroderma .builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of curren

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Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis responses (e.g., mutation of scleroderma autoantigens in cancers), as well as potential roles as active mediators of damage of specific tissues. An understanding of the mechanisms underlying this extraordinary specificity may provide novel therapeutic targets or disease monitoring and management strategies.

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Historical Perspective of SclerodermaThere are key historic events that are relevant, but it was not until the twentieth century that scleroderma emerged as a concept for multisystem disease. This chapter reviews key aspects of early history that relates to scleroderma and then focuses on the modern era that really reflects advances in

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Genetic Factorsns is poor, their concordance rates are higher for autoantibodies and fibrotic transcript profile. International collaborations have enabled sufficiently powered, genome-wide association studies leading to enormous progress in the field of SSc genetics. In the HLA region, the strongest associations

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