| 书目名称 | SH Domains | | 副标题 | Structure, Mechanism | | 编辑 | Natalya Kurochkina | | 视频video | | | 概述 | Provides state-of-the-art review on the important roles of SH domains.Gives outlook on future applications in stem cell therapy and biomaterials.Written by international experts from the field.Include | | 图书封面 |  | | 描述 | .This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.. | | 出版日期 | Book 2015 | | 关键词 | PTKs; Protein interaction; Protein tyrosine kinases; Regulatory domains; SH domains; Src proteins; Protein | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-20098-9 | | isbn_softcover | 978-3-319-37252-5 | | isbn_ebook | 978-3-319-20098-9 | | copyright | Springer International Publishing Switzerland 2015 |
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发表于 2025-3-21 19:51:52
