Titlebook: Reverse Transcriptase Inhibitors in HIV/AIDS Therapy; Vassil St.Georgiev,Gail Skowron (Chief),Joep M. A. Book 2006 Humana Press 2006 AIDS.

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Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

Spirometry

Reverse Transcriptase Inhibitors in HIV/AIDS Therapy978-1-59745-085-0

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Zidovudine, Lamivudine, and Abacavir,ZDV alone or in combination with other nucleoside analogs, these benefits were of limited durability because of incomplete virological suppression and the emergence of resistant HIV strains. ZDV is currently approved for the treatment of HIV infection in combination regimens with potent antiretrovir

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Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors,ass. When considering these agents in newly infected or ARV-naive patients, the rate of transmitted resistance, especially in areas in which NNRTIs have been used extensively, may ultimately limit the usefulness of this class of therapeutics. As the incidence of transmission of NNRTI resistance incr

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New Reverse Transcriptase Inhibitors in Development,on-nucleoside RT inhibitors (NNRTIs), first discovered in the early 1990s (., and the nucleotide RT inhibitors. As described in detail in the earlier chapters of this volume Chapter 11 to Chapter 14 the NNRTIs act by noncompetitive binding to a hydrophobic pocket on the p66 subunit of the RT enzyme.