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Titlebook: Research in Congenital Hypothyroidism; François Delange,Delbert A. Fisher,Daniel Glinoer Book 1989 Plenum Press, New York 1989 assessment.

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Resistance to Thyroid Hormones and Screening for High Thyroxine at BirthResistance to thyroid hormone encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to a supply of thyroid hormone which under normal circumstances would be excessive. The defects have always been partial, because if complete, they would probably be incompatible with life.
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Cervical Ultrasound in Congenital HypothyroidismAs far as congenital hypothyroidism (C. H) is concerned, the usefulness of cervical ultrasound (C. U. S) has not been established yet, although some investigators had called attention to its potential benefits as far back as 1984. (1, 2).Theoretically, the aims of C. U. S in CH may be threefold:
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Book 1989tardation due to thyroid hormone deficiency during the early months of life. During the past decade screening programs have become routine throughout most of the industrialized world and many questions relating to implementation, organization and quality control of such programs have been largely re
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Role of the Maternal Carrier Proteins in the Supply of Thyroid Hormones to the Feto-Placental Unit: nificant amount., nor are implicated in the development of the fetus in general, or of the fetal CNS in particular.. Nevertheless, for a number of reasons (some of which have been discussed in.), the validity of this view appeared to us to be open to doubt; we therefore initiated studies (ca 1980) s
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Maturation of Thyroid Hormone Actionsrns have few if any signs of their chemical hypothyroidism, and length, weight and head circumference at birth are normal for gestation age. Moreover, IQ and neurological function parameters are normal in the vast majority of hypothyroid newborns detected by chemical screening and treated in the ear
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Regulation of Intracellular Thyroid Hormone Concentrations in the Fetusmulation of skeletal maturation, the diferentiation of central nervous system, and they seem to regulate other processes such as the maturation of lung and the process of non-shivering thermogenesis in the neonate. Most of the information available is based on experimental models, mainly in the rat
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Action of Thyroid Hormones on Brain Developmention of cretinism are found in the publication of the Royal Commission of the King of Sardaigna in 1848.. Cretinism is described as “a person with abnormal corporal development and mental retardation. They are born in regions were many such cases are found and endemic goiter is prevalent”.
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