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Titlebook: Reproductive Toxicology; In Vitro Germ Cell D Jesús Mazo Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Survival of Human Neoplastic Germ Cellsed to the birth cohort rather than to the age of the patients (Møller ., 1993; Bergström ., 1996). These phenomena suggest that differentiating testicular germ cells in the fetal or perinatal period may be especially prone to the negative influence of yet unknown environmental factors (Skakkebæk ., 1998).
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Culture Systems for Germ Cells from Mouse Embryo: Primordial Germ Cells and Oocytesof these cells, will also briefly reviewed. In the second part, an . culture method for fetal mouse oocyte is described. This method can be used to address several problems concerning the early female gametogenesis. Finally, a short outline about the potential application of these methods for . genotoxicological tests is given.
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Models for the Investigation of Reproductive Toxicology in the Testisve you a particular example of the action of a Leydig cell toxicant. This will illustrate the advantages of . models. Finally, I would like to summarise our proposals for a new project to develop . models for toxicity testing using the Leydig cell.
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Analysis of Gene Regulation in Sertoli Cells by a Gene Trap Approachd the progress of our knowledge of the molecular mechanisms which regulate spermatogenesis. Identification of spermatogenic regulatory genes will be useful to develop an . system to test potential pharmacotoxicological agents.
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