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Titlebook: Regulation of Target Cell Responsiveness; Kenneth W. McKerns,Asbjørn Aakvaag,Vidar Hansson Book 1984 Plenum Press, New York 1984 Insulin.e

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Stage-Dependent Differences in FSH Binding and Cyclic Nucleotide Secretion and Metabolism during theAMP and cGMP phosphodiesterases could be detected which were related to specific stages of spermatogenesis. FSH binding (per cm stage) increased gradually between stages VII and IX and then, after remaining relatively constant, was elevated further in stages XIV-I. Thereafter, binding fell to a nadi
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The Role of Protein Phosphorylation in Insulin Actionansport processes and protein synthesis. However, in spite of extensive studies the mechanism of insulin action at the molecular level is an unsolved problem (Walaas and Horn, 1981). At the present time there is general agreement that the initial event in insulin action involves interaction of the h
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The Role of the Cytoskeleton in the Responses of Target Cells to Hormones most if not all cells, namely microtubules (diameter, 25 nm), intermediate filaments (diameter, 10 mn) and microfilaments (diameter 6 nm). The basic component of microtubules is the protein tubulin; intermediate filaments contain a variety of proteins (keratin, desmin, and vimentin) (Lazarides, 198
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Calmodulin — A Receptor for Calcium Modulating Hormone Responsivity action of peptide hormones on mammalian cells is a specific case in point. Target cells recognize the hormone through specific receptors on the outer surface of their plasma membrane. The binding of hormone to receptor initiates a series of rapid events which eventually translates this external sig
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