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Titlebook: Recent Advances in Musculoskeletal Oncology; Atsumasa Uchida,Keiro Ono Conference proceedings 1992 Springer Japan 1992 bone.cancer.chemoth

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Principles for Designing Scientific Investigations of Orthopedic Malignanciess. Since tumors of the bone or soft tissue are rare, multi-institutional study is indispensable. One example, chemotherapy of osteosarcoma, is reviewed and principles for conducting a clinical investigation are described.
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Preoperative Chemotherapy for the Treatment of Osteosarcomae most important prognostic factor. The aims of preoperative chemotherapy are (1) to control micrometastasis, (2) to control the primary tumor, and (3) to assess the effectiveness of the drugs used by grading of primary tumor necrosis.
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Intra-Arterial Cisplatin Chemotherapy for Osteogenic Sarcomay has been tried in many cancer centers [1–3], with the resultant benefits of controlling micrometastasis, permitting the analysis of the response of the tumor to chemotherapy, and providing a better chance to save the endangered limb by reducing and consolidating the tumor volume [4]. Intra-arteria
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Clinical Study of Recombinant Human Granulocyte Colony-Stimulating Factor in Patients Undergoing Intently recombinant forms of four human hematopoietic colony-stimulating factors have been purified [1–3], and their potential clinical application seem to be very promising for prevention of bone marrow suppression by chemotherapy. Reports on the effect of recombinant human granulocyte colony-stimula
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Future Directions in the Management of Malignant Bone Tumors survival rate of patients with primary malignant bone tumors. There is some evidence that current chemotherapy programs have reached a plateau in their effect on survival, and that further improvements are going to be difficult both to obtain and to detect. This chapter describes some of the remain
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