Titlebook: Re-irradiation: New Frontiers; Carsten Nieder,Johannes A. Langendijk Book 20111st edition Springer-Verlag Berlin Heidelberg 2011 Cancer.Ra

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Normal Tissue Tolerance to Reirradiation,oregional recurrences in previously irradiated areas might increase. Consequently, the need for additional therapeutic measures providing local control and/or symptom palliation along different lines of treatment has emerged. This has resulted in increasing requests for delivering a second course of

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Fractionation Concepts,t calculations are provided. The vast majority of published reirradiation series consist of retrospective data or small prospective studies with limited statistical power. In addition, the typical patient populations are more heterogeneous than in first-line radiotherapy studies. For example, patien

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Reduced Normal Tissue Doses Through Advanced Technology,d compared with the first treatment series. Results with traditional radiotherapy techniques have been disappointing because of the poor conformality of the dose distributions: radiation doses were either insufficiently low resulting in poor rates of tumor control or substantial toxicity was the con

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Brain Tumors,ystem toxicity, especially radionecrosis, which may occur several months to years after treatment. There is, however, a lack of prospective data addressing this approach. Re-irradiation of brain tumours is attracting more interest as our understanding of the tolerance of the brain to radiation evolv

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