Titlebook: p53 Suppressor Gene; Tapas Mukhopadhyay,Steven A. Maxwell,Jack A. Roth Book 1995 Springer-Verlag Berlin Heidelberg 1995 Promoter.cancer.ge

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Gene Structure,uman tumor cell lines and solid tumors.’ Rapid progress has been made in the past few years in understanding the role of . in the biology of the tumor ce11.. Molecular isolation and characterization of this gene enabled determination of how . suppresses or inhibits the proliferation of tumor cell gr

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Wild-Type versus Mutant ,,om a transformed mouse cell line coprecipitated a nuclear phosphoprotein of 53,000 molecular weight, hence called . The human . protein is composed of 393 amino acids and is located in the nucleus. . is present in all tissues but in such low quantities. that it is difficult to detect by immunohistoc

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Biophysical and Biochemical Properties of the , Protein,iption as a mechanism of . action in controlling cell growth. The protein does resemble a transcription factor. in that it has an acidic domain that can transactivate reporter genesG. and a basic carboxyl terminal domain that can bind nonspecifically to DNA. (Fig. 4.1).

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1431-0414 d p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs.

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Book 1995icates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activi

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