| 书目名称 | Pulmonary Actions of the Endothelins | | 编辑 | Roy G. Goldie,Douglas W. P. Hay | | 视频video | | | 丛书名称 | Respiratory Pharmacology and Pharmacotherapy | | 图书封面 |  | | 描述 | The biology of the family of endogenous autocrine peptides known as the endothelins (ETs) has been a source of intense study for researchers since 1988, following the identification of ET-l as the previously described endothelium-derived contractile factor. Initial interest focussed on the actions of the ETs in the cardiovascular system, and this remains the pri mary source of published work involving these peptides. Importantly, evi dence is mounting for a significant mediator role for ET-l in cardiovascu lar diseases including systemic hypertension and congestive heart failure. However, it was also recognized early on that the ETs exert an array of powerful actions in the respiratory tract, many of which prompted specula tion concerning mediator roles for ET-l in several lung diseases including asthma and pulmonary hypertension. In recent years the evidence for the involvement of ET-l in lung diseases has become more compelling. There is now real hope and anticipation that novel ET receptor antagonists may eventually be used therapeutically against asthma and other major lung pathologies. It is this atmosphere of excitement created by new discoveries and the increasing scient | | 出版日期 | Book 1998 | | 关键词 | asthma; biology; clinical research; development; diseases; endothelium; enzymes; growth; research; signal tra | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-0348-8821-9 | | isbn_softcover | 978-3-0348-9786-0 | | isbn_ebook | 978-3-0348-8821-9 | | copyright | Springer Basel AG 1998 |
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发表于 2025-3-21 16:57:03
