| 书目名称 | Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology |
| 编辑 | Denis Corbeil |
| 视频video | |
| 概述 | Provides exciting new research on prominin-1/CD133 and its role in expression in cancer stem cells.Explores the role of the prominin family and presents new information regarding the regulation of pro |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primar |
| 出版日期 | Book 2013 |
| 关键词 | gene regulation; hematopoietic stem cells; progenitor cells; prominins |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-5894-4 |
| isbn_softcover | 978-1-4899-8692-4 |
| isbn_ebook | 978-1-4614-5894-4Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 19:39:19
