| 书目名称 | Presenilins and Alzheimer’s Disease |
| 编辑 | S. G. Younkin,R. E. Tanzi,Y. Christen |
| 视频video | |
| 丛书名称 | Research and Perspectives in Alzheimer‘s Disease |
| 图书封面 |  |
| 描述 | The discovery in 1995 that defects in the novel presenilin genes harbor defects which cause up to half of all cases of early onset familial Alzheimer‘s disease cases has rapidly led to the creation of a new and exciting sub-field in Alzheimer‘s disease research. This has clearly been evidenced by the fact that over 250 papers have now been published regarding the presenilins since their identification in 1995. One of the earliest findings regarding the role of the presenilins in Alzheimer‘s disease was the discovery that like familial Alzheimer‘s disease mutations in the amyloid ß protein precursor gene, those in the presenilins lead to dramatically increased production of ß-amyloid in the brains of AD patients. Additionally, the presenilins appear to play roles in programmed cell death (apoptosis) and in CNS development. The provocative chapters in this book written by some of the most highly respected experts in the area of Alzheimer‘s disease research present some of the latest information concerning the biological function of the presenilins and how defects in these genes cause Alzheimer‘s disease. The knowledge contained in this volume should help to accelerate ongoing attempt |
| 出版日期 | Conference proceedings 1998 |
| 关键词 | Alzheimer‘s disease; Alzheimer´s disease; activation; biology; brain; cell; cell death; dementia; genetics; m |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-72103-8 |
| isbn_softcover | 978-3-642-72105-2 |
| isbn_ebook | 978-3-642-72103-8Series ISSN 0945-6066 Series E-ISSN 2196-310X |
| issn_series | 0945-6066 |
| copyright | Springer-Verlag Berlin Heidelberg 1998 |
发表于 2025-3-21 19:47:40
