| 书目名称 | Poly(ADP-Ribose) Polymerase | | 副标题 | Methods and Protocol | | 编辑 | Alexei V. Tulin | | 视频video | | | 概述 | Includes updated, cutting-edge methods and protocols for the study of PARP research.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from th | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | This book presents multiple new and classical methods for studying the vital poly-ADP-ribose (pADPr) pathway. Beginning with techniques for the detection and quantification of the product of poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection of variation in pADPr production during the cell cycle, the volume continues with sections on the identification of pADPr protein acceptors, methods focusing on studying molecular mechanisms of PARP functions in eukaryotic cells, particularly those involved in control of DNA repair and oxidative stress, as well as in expression regulation, approaches to the in vitro reconstitution of PARP-1 interaction with chromatin, the development and testing of small molecule PARP inhibitors, and the functions of understudied members of PARP family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. .Authoritative and practical, .Poly(ADP-Ribose) Polymerase: Methods and Protocols, Second Edition. serves | | 出版日期 | Book 2017Latest edition | | 关键词 | PARP-1; pADPr; Enzymatic activity; DNA repair; Protein acceptors; PARP inhibitors | | 版次 | 2 | | doi | https://doi.org/10.1007/978-1-4939-6993-7 | | isbn_softcover | 978-1-4939-8361-2 | | isbn_ebook | 978-1-4939-6993-7Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media LLC 2017 |
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发表于 2025-3-21 16:07:12
