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Titlebook: Parkinson‘s Disease and Related Disorders; P. Riederer,H. Reichmann,M. Gerlach Conference proceedings 2006 Springer-Verlag Vienna 2006 Dem

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Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson’s diseasee for sporadic PD pathology was developed by Braak et al. assuming that the abnormal deposition of α-synuclein indicates the intracellular process responsible for clinical PD. This paradigm has merit in corralling patients with similar cellular mechanisms together and determining the potential seque
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A short overview on the role of α-synuclein and proteasome in experimental models of Parkinson’s diseases impaired both in sporadic and inherited forms of Parkinsonism. In the present paper we focus on the role of the pre-synaptic protein α-synuclein in altering the proteasom based on the results emerging from experimental models showing a mechanistic chain of events between altered α-synuclein, prote
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The role of protein aggregates in neuronal pathology: guilty, innocent, or just trying to help?d cell populations and they have trapped the mutant disease protein. Instead of a good reputation, however, protein aggregates have received incriminations, because they are consistently seen at the site of crime. Reviewing the arguments, crucial evidence has become known that (a) the specific neuro
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C. Powell MB, FRCPidungen führen sollen. Dieses Sammelsurium von Erkenntnissen, Konzepten und Schlussfolgerungen ist in unterschiedlichen Zusammenhängen entstanden und rundet das Thema Prozessmanagement ab. Jedem Schnipsel wird nur ein kurzes Kapitel gewidmet – wer mehr darüber erfahren möchte, kann diese Information
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