Titlebook: Parkinson‘s Disease; Methods and Protocol M. Maral Mouradian Book 2001 Humana Press 2001

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Molecular Biology of Dopamine-Induced ApoptosisHowever, a major advance has been recently made with the introduction of the concept of apoptosis as the route leading this specific neuronal population to degeneration. Apoptosis, or programmed cell death (PCD), is an active, controlled program inherent in every living cell. Upon receiving certain

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Apoptotic Morphology in Phenotypically Defined Dopaminergic Neurons of the Substantia Nigraatural cell death and death induced either by developmental injury to the target striatum or by dopamine terminal destruction with the neurotoxin 6-hydroxydopamine (6-OHDA). In each of these paradigms, in order to relate experimental investigations specifically to dopamine neurons, the dopaminergic

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The Role of Nitric Oxide in Parkinson’s Diseases are dying. Without exception, the frequency of these disorders is increasing dramatically as the proportion of elderly in our society grows. The search for efficacious therapies, if not to prevent, at least to slow down or halt the progression of these diseases, is of major public health importanc

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Oxidative Stress Indices in Parkinson’s Disease pars compacta (SNpc) and projecting terminals to the striatum. The disease is best characterized biochemically as a deficiency of striatal dopamine. The mechanism of neurodegeneration remains an enigma despite a large body of investigation and several hypotheses (.–.). In the past decade much has b

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Immunochemical Analysis of Dopamine Transporters in Parkinson’s Diseasefocus since Hornykiewicz first reported a dopamine deficiency in the disease (.). Antibodies to dopamine or tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, have been used to identify these neurons. Recently, considerable attention has been given to the plasma membrane dopamine

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Transcription Mechanisms for Dopamine Receptor Genessm. Like all protein coding genes, those encoding dopamine receptors are subject to this form of regulation as well. Modifications in dopamine receptors have been implicated in a number of neurobehavioral disorders, including Parkinson’s disease and schizophrenia, as well as in the complications of