Titlebook: Nutrition, Exercise and Epigenetics: Ageing Interventions; Byung Pal Yu Book 2015 The Editor(s) (if applicable) and The Author(s), under e

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Donald K. Ingram,Julie A. Mattison,Rafael de Cabo,George S. Rothy from home, is placed between Spain and Italy. This village in Southern France was far from the stark Parisian realities described by James Baldwin in . (1955) and visiting Baldwin in this ‘very expensive kingdom’ became a ‘spiritual fix’ (Phillips 1987). The repeated tributes Caryl Phillips paid t

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Nutritional Epigenetics and Aging,a change in phenotype without a change in genotype. The field of epigenetics is quickly growing especially because environmental and lifestyle factors can epigenetically interact with genes and determine an individual’s susceptibility to disease. Interestingly, aging is associated with substantial c

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Dietary Restriction, Dietary Design and the Epigenetics of Aging and Longevity,ants of, aging and longevity. Yet few data connect these directly. Epigenetics changes with age; in particular DNA methylation and histone acetylation have been well studied. For humans, a DNA methylation based “epigenetic clock” has been developed to track the apparent chronological age of people,

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Anti-inflammatory Action of Calorie Restriction Underlies the Retardation of Aging and Age-Related seases and stress. This chapter reviews the molecular mechanisms of CR’s anti-inflammatory actions during aging. The crux of CR’s ability to attenuate age-related chronic inflammation is related to its power to maintain redox status by modulating oxidative stress during aging. Here, for better molec

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Hormonal Influence and Modulation in Aging, target cells become insensitive to certain hormones, thereby causing aging-related disorders. For example, a reduction in the levels of growth hormone (GH) and its peripheral effector, insulin-like growth factor-1 (IGF-1), causes physical frailty due to loss of bone and lean muscle mass in humans.

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Epigenetic Modulation of Gene Expression by Exercise,ge-related disorders and lifestyle-associated diseases such as type 2 diabetes mellitus, cancer, cardiovascular disorders and various types of inflammation, thereby extending healthy lifespan. Recent studies revealed that epigenetic mechanisms such as DNA methylation, histone modifications and micro

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Metabolic and Antioxidant Adaptation to Exercise: Role of Redox Signaling,s. As research advances more evidence has revealed a more complete role of ROS under both physiological and pathological conditions. The current chapter will review the role of redox sensitive signaling pathways in conferring exercise-induced major physiological and cellular adaptations in skeletal

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Sarcopenia and Its Intervention,, independence, and quality of life in the elderly. Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and often

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The Role of Functional Foods and Their Bioactive Components in Bone Health,illions of men and women worldwide and as such is a major public health problem. Certain lifestyle factors, including nutrition, are known to reduce the risk of developing osteoporosis and therefore play an important role in bone health. Epigenetics refers to heritable changes in gene expression tha

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Nutritional Interventions for Cardiovascular Aging and Age-Related Cardiovascular Diseases, cardiovascular aging contribute to the association between aging and CVDs. Most developed countries would benefit from the development of novel therapeutics to control cardiovascular aging because they are confronted with an aged society. Dietary restriction (DR) including caloric restriction (CR)