| 书目名称 | Nuclear Export of Viral RNAs | | 编辑 | Joachim Hauber,Peter K. Vogt | | 视频video | | | 概述 | Includes supplementary material: | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | In eukaryotic cells, the nuclear genome and its transcriptional apparatus is separated from the site of protein synthesis by the nuclear envelope. Thus, a constant flow of proteins and nucleic acids has to cross the nuclear envelope in both directions. This transport in and out of the nucleus is mediated by nuclear pore complexes (NPCs) and occurs in an energy and signal-dependent manner. Thus, nucleocytoplasmic translocation of macro molecules across the nuclear envelope appears to be a highly specific and regulated process. Viruses that replicate their genome in the cell nucleus are therefore forced to develop efficient ways to deal with the intracellulZlr host cell transport machinery. Historically, investigation of Polyomavirus replication allowed identification ofsequences that mediate nuclear import, which led subsequently to our detailed understanding of the cellular factors that are involved in nuclear import. Transport ofmacromolecules in the opposite direction, however, is less well understood. The investigation of retroviral gene expression in recent years pro vided the first insights into the cellular mechanisms that regulate nuclear export. In particular, the detaile | | 出版日期 | Book 2001 | | 关键词 | Activation; Herpes Virus; RNA; cytoplasm; nuclear export; nucleocytoplasmic transport; protein; proteins; vi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-56597-7 | | isbn_softcover | 978-3-642-62522-0 | | isbn_ebook | 978-3-642-56597-7Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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发表于 2025-3-21 16:52:13
