| 书目名称 | Novel Developments in Stem Cell Mobilization |
| 副标题 | Focus on CXCR4 |
| 编辑 | Stefan Fruehauf,W. Jens Zeller,Gary Calandra |
| 视频video | |
| 概述 | A concise review of the current status of knowledge and future developments of CXCR4 will be presented.Contributors are internationally leaders in the field.A comprehensive treatment of the subject wi |
| 图书封面 |  |
| 描述 | Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented. |
| 出版日期 | Book 2012 |
| 关键词 | CXCR4; Cancer Research; Mobilization; Plerixafor; Stem Cell |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-1960-0 |
| isbn_softcover | 978-1-4899-9376-2 |
| isbn_ebook | 978-1-4614-1960-0 |
| copyright | Springer Science+Business Media, LLC 2012 |
发表于 2025-3-21 18:09:23
